Go to Add/Remove Programs and remove things that are used 'rarely', but only things that you have recently downloaded because like VC said there are some programs that need to stay in place.
Also,you can run the clean-up wizard-it gets rid of useless temp files.
Make sure you check security because you never know when a DL game has a trogan.
My mom DL'ed " maui wowi" and got a heck of a virus.
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