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Gilbert's syndrome (pr. Zhil-bear), often shortened to the acronym GS, is the most common hereditary cause of increased bilirubin, and is found in up to 5% of the population. The main symptom is otherwise harmless jaundice which does not require treatment, caused by elevated levels of unconjugated bilirubin in the bloodstream (hyperbilirubinemia).
The source of this hyperbilirubinemia is reduced activity of the enzyme (glucuronyl transferase) which conjugates bilirubin and some other lipophilic molecules. Conjugation renders the bilirubin water-soluble and suitable for excretion via the kidneys.
Gilbert's syndrome was first described by French gastroenterologist Augustin Nicolas Gilbert and co-workers in 1901.[1]
Sad that I understand most of that.
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Mortimer Brewster: No, no. I'm not a Brewster. I'm the son of a sea-cook! Ha! Ha! Chaaaaarrrge!
Cab Driver: And I'm not a cab driver, I'm a coffee pot!
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